The 2010 Anime Bracket was the second annual Anime Bracket.
| Asuka Langley Soryu | Champion |
| Haruhi Suzumiya |
Runner-Up |
| Sango |
Final Four |
| Yoruichi Shihouin |
Final Four |
| Rei Ayanami |
Elite Eight |
| Meilin Rae |
Elite Eight |
| Madison Taylor |
Elite Eight |
| Sosuke Aizen |
Elite Eight |
| Rei Hino |
Sweet Sixteen |
| Kyon |
Sweet Sixteen |
| Li Syaoran |
Sweet Sixteen |
| Loly Aivirrne |
Sweet Sixteen |
| Misato Katsuragi |
Sweet Sixteen |
| Ryoko Asakura |
Sweet Sixteen |
| Rangiku Matsumoto |
Sweet Sixteen |
| Orihime Inoue |
Sweet Sixteen |
